Isolated bladder dysfunction in human T lymphotropic virus type 1 infection.

نویسندگان

  • Marcus Tulius Silva
  • Francisco Coutinho
  • Ana Cláudia Leite
  • Ramza Cabral Harab
  • Abelardo Araújo
  • Maria José Andrada-Serpa
چکیده

Neurogenic bladder is common in patients with human T lymphotropic virus type 1 (HTLV-1)–associated myelopathy/tropical spastic paraparesis (HAM/TSP). Here, we describe isolated neurogenic bladder dysfunction in HTLV-1–infected individuals without HAM/TSP and show that HTLV-1 proviral load is higher in such patients than it is in asymptomatic carriers. We suggest that testing for HTLV-1 antibodies should be performed for patients with neurogenic bladder of unidentified etiology. Bladder dysfunction is a very common complaint, especially among woman. Even after a comprehensive investigation, an etiologic cause cannot be determined in a considerable number of patients. HTLV-1, which is a retrovirus that is endemic in Japan, South and Central America, and Africa, is associated with different clinical conditions. Although HAM/TSP is the neurological disease that is most often associated with this retrovirus [1], other neurological conditions have also been associated with it; this recently led to the development of a broader, unified concept of a true HTLV-1 neurological complex [2]. Although bladder dysfunction is a common complaint in patients with HAM/TSP, it is not seen in neurological asymptomatic carriers (AC) [3]. We describe neurogenic bladder dysfunction in HTLV-1–infected individuals who do not fulfill the diagnostic criteria for HAM/TSP and show that the HTLV-1 proviral load in these individuals is higher than the loads in ACs and is similar to the loads in patients with HAM/TSP. Patients and methods. Since 1992, we have been searching

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عنوان ژورنال:
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

دوره 48 3  شماره 

صفحات  -

تاریخ انتشار 2009